Temporal bone histopathology of furosemide ototoxicity
نویسندگان
چکیده
منابع مشابه
Temporal bone histopathology of furosemide ototoxicity
OBJECTIVES To describe the human temporal bone pathology in two patients who incurred furosemide induced ototoxicity. PATIENTS 1) A 46-year-old woman in acute liver and renal failure treated with high doses of furosemide for anasarca who developed a rapidly progressive severe-to-profound asymmetric sensorineural hearing loss. 2) A 65-year-old woman with undifferentiated small cell carcinoma o...
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Idiopathic Sudden Hearing Loss (ISHL) is characterized by a sudden, bilateral or unilateral hearing deficit, which develops within a period of 72 hours and still poses a diagnostic and treatment challenge to otolaryngologists. Its cause and pathogenesis are still unknown. Among the theories proposed to explain its pathogenesis, we list cochlear viral infection, vascular occlusion and membrane r...
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OBJECTIVES/HYPOTHESIS To describe the histopathologic findings in the temporal bone in patients with neurofibromatosis type 2 (NF2). The literature contains limited data on otopathology of NF2. STUDY DESIGN Basic science study. METHODS Twenty-six temporal bones from 16 patients with NF2 were examined by light microscopy. The diagnosis of NF2 was made on the basis of bilateral cochleovestibu...
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متن کاملSildenafil and furosemide associated ototoxicity: consideration of drug-drug interactions, synergy, and broader clinical relevance.
Drug-induced ototoxicity, particularly those involving phosphodiesterase type 5 (PDE-5) inhibitors, is considered to be rare and to our knowledge such an adverse effect has not been reported in Canada. Here we present a case of a 77-year old man initiated on a sildenfil regimen for the treatment of pulmonary hypertension, who developed sudden bilateral hearing loss after taking sildenafil, in t...
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ژورنال
عنوان ژورنال: Laryngoscope Investigative Otolaryngology
سال: 2017
ISSN: 2378-8038
DOI: 10.1002/lio2.108